The role of TGF-Beta in diabetic nephropathy

Almossawi, Ahmed Issa; Mahdi, Wejdan Thamir

doi:10.29350/qjps.2026.170893.1075

The role of TGF-Beta in diabetic nephropathy

10.29350/qjps.2026.170893.1075

Volume 31, Special
Summer 2026

Document Type : IAAQC Conference

Authors

Ahmed Issa Almossawi ¹

Wejdan Thamir Mahdi ²

¹ العراق/جامعة القادسية /كلية العلوم /قسم علوم الحياة

² العراق، جامعة القادسية، كلية العلوم، قسم علوم الحياة

Abstract

This study aimed to evaluate the role of a panel of biomarkers, including TGF-β1, IL-6, mTOR, and total antioxidants, in the development of diabetic nephropathy, alongside traditional biochemical markers. The study included 100 participants: 50 patients with type 2 diabetes and 50 healthy individuals as a control group.
The results showed elevated levels of HbA1c, creatinine, TGF-β1, IL-6, and mTOR in the patients compared to the healthy individuals, while albumin, antioxidant, and eGFR levels were decreased.

These findings suggest that increased TGF-β1 and mTOR, along with impaired antioxidant defenses, play a significant role in the development of diabetic nephropathy, and that elevated IL-6 contributes to the promotion of inflammation associated with the disease.

Keywords

diabetic nephropathy,TGF-&beta

1, interleukin-6 (IL-6)