Micellar Systems Loaded with Iron Oxide Nanoparticles: Rheological and Thermodynamic Evaluation for Potential Drug Delivery Applications

AL-mosawy, Tamara Adnan

doi:10.29350/qjps.2026.171736.1123

Micellar Systems Loaded with Iron Oxide Nanoparticles: Rheological and Thermodynamic Evaluation for Potential Drug Delivery Applications

10.29350/qjps.2026.171736.1123

Volume 31, Special
Summer 2026

Document Type : IAAQC Conference

Author

Tamara Adnan AL-mosawy

621,218,706

Abstract

This study explores the preparation and characterization of mixed surfactant systems composed of cetyltrimethylammonium bromide (CTAB) and sodium dodecylbenzene sulfonate (SDBS) at various ratios and temperatures (283–313 K). Iron oxide (Fe3O4) nanoparticles were synthesized via a green method and characterized using FT-IR, SEM, EDX, and TEM, confirming their morphology, composition, and nanoscale structure. Rheological analysis revealed that the CTAB:SDBS (7:3) ratio exhibited the highest viscosity, ranging from 0.0018 to 0.0260 × 10² Pa•s. Thermodynamic evaluation indicated spontaneous micellization (ΔG° = −2.25 to −4.40 kJ•mol⁻¹) and an exothermic process (ΔH = −67.270 kJ•mol⁻¹), with negative entropy values. The incorporation of amoxicillin enhanced viscosity, reaching 0.0325 × 10² Pa•s at 200 ppm, while maintaining spontaneous and exothermic behavior. The combined system containing CTAB:SDBS (7:3), amoxicillin, thyme extract, and Fe₃O₄ nanoparticles demonstrated the highest viscosity (0.0372 × 10² Pa•s) and activation energy (0.812 kJ•mol⁻¹). Thermodynamic parameters confirmed stable and spontaneous micelle formation. Overall, the results highlight the potential of these mixed micellar systems as efficient drug delivery platforms.

Keywords

Iron oxide nanoparticles (Fe3O4)

Micelle formation

promising micellar carrier

amoxicillin

green synthesis